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Null Effect of Hyperimmune Egg in Preventing Dextran Sulfate Sodium-Induced Stimulation in Rodents

Jacoby, H., Brodie, D. Wnorowski, G. and G. Moore Product Safety Labs, East Cranberry, NJ.

Background:
Administration of dextran sulfate sodium solution (DSS) in mice produces an acute immunological response. No compound tested has been shown to completely abolish development of such responses.

Study Design:
Mice were fed control or immune egg along with their regular chow for varying periods (d57-77), and then challenged with DSS, day 6 to 7 prior to necropsy.

The development of an immunological response was evaluated based on a complex formula that included: weight loss, stool consistency, colon length, and gross or occult hemoglobin-bearing fluids in the feces.

Results:
In an isolated study there was a biological trend toward protection of the upper GI tract from dextran sulfate sodium challenge by immune egg as compared with control egg. However, the results were not statistically significant and nor the results replicable.